The IA64 architecture was developed by Hewlett-Packard and Intel to supersede the 32bit x86 CPU generation. Implementation exist with the Itanium and Itanium 2. The architecture is somewhat non CISC nor RISC and designed using EPIC (Explicitly Parallel Instruction Computing) ideas.
It is targetting the high performance, scientific computing sector and enterprise server.
Does cross build - should work more or less. Real hardware wanted.